Translating the epitranscriptome
نویسندگان
چکیده
منابع مشابه
Translating the epitranscriptome
RNA modifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been revealed. Novel experimental methods have enabled...
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The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps revea...
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RNA is decorated by various chemical modifications that affect the stability and localization of this fragilemolecule. These diverse, highly conserved, covalent modifications also help RNA perform its crucial roles in the cell. Over 100 RNAmodifications have been identified, primarily in noncoding RNAs (e.g., tRNA and rRNA). Less is known about the chemical modification of mRNA, although there ...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2016
ISSN: 1757-7004
DOI: 10.1002/wrna.1375